Âõ²©ÌåÓý

µ±Ç°Î»ÖãºÊ×Ò³ > ¿Í»§Ö§³Ö > °ÄÁúͨѶ >

Âõ²©ÌåÓý:Âõ²©ÌåÓý·½°ÄÁú¿Æ¼¼¼òѶµÚ33ÆÚ£¨2013Äê10Ôºţ©

·¢²¼Ê±¼ä£º2013-10-31 À´Ô´£ºÂõ²©ÌåÓý·½°ÄÁú


 
 
 
2013ÄêµÚ10ÆÚ
Ôð±à£ºÑз¢²¿
  
    
 
 
   
 
1¡¢Å©Òµ²¿·¢²¼ÖлªÈËÃñ¹²ºÍ¹úÅ©Òµ²¿Áî(2013ÄêµÚ2ºÅ)¡¶ÊÞÓô¦·½Ò©ºÍ·Ç´¦·½Ò©¹ÜÀí°ì·¨¡·£¬×Ô2014Äê3ÔÂ1ÈÕÆðÊ©ÐС£¡¶°ì·¨¡·¹æ¶¨´¦·½Ò©¡¢·Ç´¦·½Ò©ÐëÔÚ±êÇ©ºÍ˵Ã÷ÊéÉÏÂõ²©ÌåÓý·Ö±ð±ê×¢“ÊÞÓô¦·½Ò©”¡¢“ÊÞÓ÷Ǵ¦·½Ò©”×ÖÑù£»ÊÞÓô¦·½Ò©Âõ²©ÌåÓýµ±Æ¾ÊÞÒ½´¦·½¼ã·½¿ÉÂòÂô¡£
 
2¡¢¹ú¼ÒÊÞÒ©Âõ²©ÌåÓýÆ·×·ËÝÐÅϢϵͳ³É¹¦Íê³É²âÊÔ¡£Í¨¹ý´Ë´ÎÑéÖ¤²âÊÔ£¬·¢ÏÖÁ˹ú¼ÒÊÞÒ©Âõ²©ÌåÓýÆ·×·ËÝÐÅϢϵͳ¡¢Êý¾Ý²É¼¯É豸£¨PDA£©ÔÚʵ¼ÊÉúÂõ²©ÌåÓýÂõ²©ÌåÓýÓÃÖдæÔÚµÄһЩ²»×㣬ÏîÄ¿×齫¾¡¿ìÖƶ¨³öÂõ²©ÌåÓý¶Ô´ëÊ©£¬½øÒ»²½ÍêÉÆϵͳ£¬Ìá¸ß×·ËÝÐÅϢϵͳµÄÔËÐÐÎȶ¨ÐÔ¡£
 
3¡¢Ñо¿·¢ÏÖ£¬Ã»ÓÐÖ°©ÐÔµÄÓлúÉéÔÚ¶¯Îï×éÖ¯ÄÚ»áת±ä³ÉÎÞ»úÉ飬ŷÃË¡¢ÈÕ±¾µÈ¹ú¼Ò½ûÖ¹ÉéÓÃÓÚ¶¯ÎïËÇÁÏ¡£½üÈÕÃÀ¹ú¶à¼Ò×éÖ¯¶ÔFDAʩѹ£¬ÒªÇ󾡿쳷Ïú¾ø´ó¶àÊýÓÃÓÚ¼¦¡¢»ð¼¦¡¢ÖíµÄº¬É鶯ÎïËÇÁÏÐí¿É¡£¼øÓÚ´Ë£¬ÃÀ¹úFDA½«³·Ïú101ÏÉ鶯ÎïËÇÁÏÐí¿Éµ±ÖеÄ98Ïî¡£
 
4¡¢±¾ÔÂÊÞÒ©ÆóÒµÓÐ15¼Òͨ¹ýGMPÈÏÖ¤£¬2¼ÒÔ­Áϳ§£¬1¼Òн¨£¬4¼ÒÔ­Ö·¸ÄÀ©½¨¡£ÆäÖÐÂõ²©ÌåÓýÈ«Ãæͨ¹ý¸´Ñ飬°üÀ¨·ÛÕë¼Á¡¢·Û¼Á/É¢¼Á/Ô¤»ì¼Á/¿ÅÁ£¼Á£¨º¬ÖÐÒ©ÌáÈ¡£©/Ƭ¼Á¡¢×îÖÕÃð¾úСÈÝÁ¿×¢Éä¼Á£¨º¬ÖÐÒ©ÌáÈ¡£©/×îÖÕÃð¾ú´óÈÝÁ¿·Ç¾²Âö×¢Éä¼Á£¨º¬ÖÐÒ©ÌáÈ¡£©/¿Ú·þÈÜÒº¼Á£¨º¬ÖÐÒ©ÌáÈ¡£©¡¢×îÖÕÃð¾ú×Ó¹¬×¢Èë¼Á£¨º¬ÖÐÒ©ÌáÈ¡£©¡¢×îÖÕÃð¾úÈé·¿×¢Èë¼Á¡¢Ïû¶¾¼Á£¨¹ÌÌ壩¡¢Ïû¶¾¼Á£¨ÒºÌ壩¡¢É±³æ¼Á£¨ÒºÌ壩¡£
 



 
 
 
Å©Òµ²¿ÐÂÅú×¼ÊÞÒ©£¨ÒßÃç³ýÍ⣩Ŀ¼¸üУº
Æ·Ãû ÉúÂõ²©ÌåÓý³§Ãû³Æ ·ÖÀà Ö¤ÊéºÅ ±¸×¢
»Ç°·ÂÈßÁàºÄƶþ¼×ÑõÜÐà¤ÈÜÒº Çൺ¿µµØ¶÷¶¯ÎïÒ©ÒµÓÐÏÞ¹«Ë¾¡¢Çൺ¿µµØ¶÷Ò©Òµ¹É·ÝÓÐÏÞ¹«Ë¾¡¢Î«·»´ó³ÉÉúÎ﹤³ÌÓÐÏÞ¹«Ë¾¡¢Î«·»Åµ´ïÒ©ÒµÓÐÏÞ¹«Ë¾¡¢ºÊÔóÆÕ¶÷Ò©ÒµÓÐÏÞ¹«Ë¾¡¢É½Î÷¿µµØ¶÷ºãÔ¶Ò©ÒµÓÐÏÞ¹«Ë¾ ËÄÀà £¨2013£©ÐÂÊÞÒ©Ö¤×Ö33ºÅ ×¢²á
Ã׶û±´ë¿ Õã½­º£ÕýÒ©Òµ¹É·ÝÓÐÏÞ¹«Ë¾ ¶þÀà £¨2013£©ÐÂÊÞÒ©Ö¤×Ö34ºÅ ×¢²á
Ã׶û±´ë¿Æ¬ Õã½­º£ÕýÒ©Òµ¹É·ÝÓÐÏÞ¹«Ë¾ ¶þÀà £¨2013£©ÐÂÊÞÒ©Ö¤×Ö35ºÅ ×¢²á
»ÆÜζàÌÇ·Û ±±¾©ÉúÌ©¶ûÉúÎï¿Æ¼¼ÓÐÏÞ¹«Ë¾¡¢°®µÏÉ­£¨±±¾©£©ÉúÎï¿Æ¼¼ÓÐÏÞ¹«Ë¾ ÈýÀà £¨2009£©ÐÂÊÞÒ©Ö¤×Ö05ºÅ ±ä¸ü×¢²á£ºÔö¼Ó°Ð¶¯Îï
ÑǼ׻ùË®ÑîËá¸Ë¾úëÄÔ¤»ì¼Á ÆÖ³ÇÂÌ¿µÉú»¯¹É·ÝÓÐÏÞ¹«Ë¾ ÎåÀà £¨2012£©ÐÂÊÞÒ©Ö¤×Ö03ºÅ ±ä¸ü×¢²á£ºÔö¼ÓÊÊÂõ²©ÌåÓýÖ¢ÄÚÈÝ£¬ÐÞ¶©Ó÷¨ÓëÓÃÁ¿
»ÆÜζàÌÇ¿Ú·þÒº ±±¾©ÉúÌ©¶ûÉúÎï¿Æ¼¼ÓÐÏÞ¹«Ë¾¡¢°®µÏÉ­£¨±±¾©£©ÉúÎï¿Æ¼¼ÓÐÏÞ¹«Ë¾¡¢±±¾©ÆÕ¶û·Íþ´ïÊÞÒ©ÓÐÏÞ¹«Ë¾ ÈýÀà £¨2008£©ÐÂÊÞÒ©Ö¤×Ö18ºÅ ±ä¸ü×¢²á£ºÔö¼Ó°Ð¶¯Îï
ÜÎÞ½×¢ÉäÒº ÄϾ©Å©Òµ´óѧ¡¢ÑïÖÐÄÁÀÖÒ©ÒµÓÐÏÞ¹«Ë¾¡¢ºþÄÏÅ©´ó¶¯ÎïÒ©ÒµÓÐÏÞ¹«Ë¾ ÈýÀà £¨2013£©ÐÂÊÞÒ©Ö¤×Ö38ºÅ ×¢²á
ÂÈÇ°Áд¼ÄÆ×¢ÉäÒº Äþ²¨µÚ¶þ¼¤Ëس§ ÈýÀà £¨2004£©ÐÂÊÞÒ©Ö¤×Ö15ºÅ ±ä¸ü×¢²á£ºÔö¼Ó¹æ¸ñ10ml£º0.5mg


Å©Òµ²¿½ø¿ÚÊÞÒ©£¨ÒßÃç³ýÍ⣩ע²áĿ¼¸üУº
Ãû³Æ ÉúÂõ²©ÌåÓý³§Ãû³Æ Ö¤ÊéºÅ
·½·Ç°àÌ«¶ûƬ  KVP KielÓÐÏÞÔðÈι«Ë¾  £¨2013£©ÍâÊÞÒ©Ö¤×Ö53ºÅ 

 
°ÄÁúÐÂÉÏÊÐÂõ²©ÌåÓýÆ·£º









  • ¹úÄÚÔÓÖ¾ÕªÒª


1. ¡¶Á½ÖÖÑÎËá¶àÎ÷»·ËØ×¢ÉäÒºÔÚÖíÌåÄÚµÄÒ©´ú¶¯Á¦Ñ§Ñо¿¡·
¡¾ÕªÒª¡¿£º Ñо¿ÖƱ¸ÁËÁ½ÖÖÎȶ¨µÄ20%ÑÎËá¶àÎ÷»·ËØ×¢ÉäÒº,°´10 mg/kgµÄ¼ÁÁ¿·Ö±ð¸øÖí¼¡Èâ×¢Éä,¹Û²ìÁ½¸öÖƼÁÔÚÖíÌåÄÚµ¥¼ÁÁ¿¼¡×¢µÄÒ©´ú¶¯Á¦Ñ§ÌØÕ÷¡£½á¹û±íÃ÷,¶àÎ÷»·ËØÔÚÖíÌåÄÚµÄÒ©ÎﶯÁ¦Ñ§ÌØÕ÷¾ù·ûºÏÒ»¼¶ÎüÊÕ¶þÊÒ¿ª·ÅÄ£ÐÍ,ÆäÖ÷ÒªµÄÒ©Îï´úл¶¯Á¦Ñ§²ÎÊý:Ïû³ý°ëË¥ÆÚ(T1/2β)·Ö±ðΪ(3.246±1.04)ºÍ(9.631±1.12)h,ҩʱÇúÏßÏÂÃæ»ý(AUC)Ϊ(10.462±0.28)ºÍ(17.525±0.14)(μg/mL)*h,´ï·åʱ¼ä(Tpeak)¼°´ï·åŨ¶È(Cmax)·Ö±ðΪ(1.427±0.16)h¡¢(1.465±0.20)μg/mLºÍ(1.694±0.15)h¡¢(1.058±0.09)μg/mL¡£ÆäÖÐÖƼÁÒ»µÄѪҩŨ¶ÈÔÚ¸øÒ©2 hºóѸËÙ½µµÍ,ΪÆÕͨעÉäÒº;ÓëÖƼÁÒ»Ïà±È,ÖƼÁ¶þÄܹ»»ºÂýÊÍ·ÅÒ©Îï,Ϊ³¤Ð§»ºÊÍÑÎËá¶àÎ÷»·ËØ×¢ÉäÒº¡£ 
 
ÎÄÏ×À´Ô´£ºÖйúÊÞÒ©ÔÓÖ¾ 2013Äê08ÆÚ 
×÷Õßµ¥Î»£º ºÓÄÏÊ¡ÊÞÒ©¼à²ìËù£» Ö£ÖݺóôàÖÆÒ©ÓÐÏÞ¹«Ë¾
 
2. ¡¶½ª»ÆËضԲÝÓã¸ÎËðÉËÐÞ¸´×÷ÓÃÑо¿¡·
¡¾ÕªÒª¡¿£ºÎªÁË¿¼²ì½ª»ÆËضԲÝÓã¸ÎËðÉ˵ÄÐÞ¸´×÷ÓÃ,Ñ¡Óû¼Óиε¨×ÛºÏÖ¢²ÝÓãΪÑо¿¶ÔÏó,ÒÔ²ÝÓã¸Î×éÖ¯ÐÎ̬¼°ÑªÇåÉú»¯Ö¸±êΪÖ÷Òª¿¼²ìÖ¸±ê,½øÐÐÁ˽ª»ÆËصĸÎËðÉËÐÞ¸´×÷Óóõ²½Ñо¿¡£ÊÔÑé½á¹ûÏÔʾ,½ª»ÆËØ°èËÇͶι7 dºó,¸øÒ©×é¡¢¶ÔÕÕÒ©×éÓë¿Õ°×¶ÔÕÕ×éÏà±È,¸Î¹¦ÄÜÏàÂõ²©ÌåÓýµÄÉú»¯Ö¸±ê(MDA¡¢AST¡¢ALT¡¢LDH¡¢T-SOD¡¢CAT¡¢GSH-PX)ÒÔ¼°¸ÎÔಡÀíµÃµ½½ÏΪÏÔÖø¸ÄÉÆ¡£½á¹û±íÃ÷,½ª»ÆËضԲÝÓã¸ÎËðÉ˾ßÓÐÒ»¶¨µÄÐÞ¸´×÷Óᣠ
 
ÎÄÏ×À´Ô´£ºÖйúÊÞÒ©ÔÓÖ¾ 2013Äê08ÆÚ 
×÷Õßµ¥Î»£ºÎ人ˮÂõ²©ÌåÓý¿ÆѧÑо¿Ëù£» Öв©Ë®Âõ²©ÌåÓýÉúÎï¼¼ÊõÓÐÏÞ¹«Ë¾
 
3. ¡¶Á½Öֻǰ·ÂÈßÁàºÄÆÈÜÒº¼Á¹à·þ¸øÒ©ÔÚ¼¦ÌåÖеıȽÏÒ©¶¯Ñ§Ñо¿¡·
¡¾ÕªÒª¡¿£º 24Ö»½¡¿µÈ⼦Ëæ»ú·Ö³É2×é,ÿ×é12Ö»(¹«Ä¸¸÷°ë),²ÉÓõ¥ÖÜÆÚƽÐÐÉè¼Æ,·Ö±ð½øÐе¥¼ÁÁ¿(60 mg/kg bw,ÒԻǰ·ÂÈßÁàºÄƼÆ)¾­¿Ú¹à·þ¸´·½ºÍµ¥·½»Ç°·ÂÈßÁàºÄÆÈÜÒºµÄÒ©¶¯Ñ§Ñо¿¡£¸øÒ©ºó°´Ô¤¶¨Ê±¼ä²É¼¯ÑªÑù,²ÉÓÃHPLC·¨²â¶¨Ñª½¬ÖÐÒ©ÎﺬÁ¿¡£Êµ²âѪҩŨ¶È-ʱ¼äÊý¾Ý,²ÉÓÃKineticaÒ©¶¯Ñ§·ÖÎöÈí¼þ¼ÆËãÒ©¶¯Ñ§²ÎÊý¡£½á¹ûÏÔʾ,¼¦µ¥¼ÁÁ¿¹à·þ»Ç°·ÂÈßÁàºÄÆÈÜÒººó,Ö÷ÒªÒ©¶¯Ñ§²ÎÊýÈçÏÂ:T1/2βΪ9.39 h,MRTΪ26.57 h,TmaxºÍCmax·Ö±ðΪ7.33 hºÍ64.69μg/mL,ClBΪ0.52 mL/(min.kg),VzΪ0.43 L/kg,AUCΪ1954.28μg/mL.h¡£¼¦µ¥¼ÁÁ¿¹à·þ¸´·½»Ç°·ÂÈßÁàºÄÆÈÜÒººó,Ö÷ÒªÒ©¶¯Ñ§²ÎÊýÈçÏÂ:T1/2βΪ8.24 h,MRTΪ26.37 h;TmaxºÍCmax15.50 hºÍ71.43μg/mL;ClBΪ0.51 mL/(min.kg),VzΪ0.36 L/kg,AUCΪ2125.81μg/mL.h,Ïà¶ÔÉúÎïÀûÓöÈΪ108.78%¡£½á¹û±íÃ÷,Óë»Ç°·ÂÈßÁàºÄÆÈÜÒºÏà±È,¸´·½»Ç°·ÂÈßÁàºÄÆÈÜÒº¹à·þºó,³ý´ï·åʱ¼äºÍ·åŨ¶ÈÃ÷ÏÔÑÓ³¤»òÔö¸ß(P<0.01)Íâ,ÆäËûÒ©¶¯Ñ§²ÎÊý¾ùÎÞÏÔÖø²îÒì(P>0.05)¡£ 
 
ÎÄÏ×À´Ô´£ºÖйúÊÞÒ©ÔÓÖ¾ 2013Äê08ÆÚ 
×÷Õßµ¥Î»£ºÑïÖÝ´óѧÊÞҽѧԺ£» ½­ËÕÅ©ÄÁ¿Æ¼¼Ö°ÒµÑ§Ôº
 
4. ¡¶ÁòËáÍ·æßà­ë¿×¢ÉäÒºÔÚ¶¯Îï¼²²¡ÖÎÁÆÖеÄÂõ²©ÌåÓýÓá·
¡¾ÕªÒª¡¿£ºÍ·æßà­ë¿ÊôÓÚ¶¯ÎïרÓõĵÚËÄ´úÍ·æß¾úËØ,¶Ôβ-ÄÚõ£°·Ã¸¸ß¶ÈÎȶ¨¡£ÁÙ´²³£ÓÃÖƼÁÁòËáÍ·æßà­ë¿×¢ÉäÒº¿É¼¡Èâ×¢Éä»òÈé·¿¹à×¢,¾ßÓÐÎüÊÕ¿ì,´ï·åʱ¼ä¶Ì¡¢ÉúÎïÀûÓöȸߵÈÓŵã,¹ã·ºÓÃÓÚÖí¡¢Å£µÈ¶¯Îï¼²²¡µÄÁÙ´²ÖÎÁÆ¡£×ÛÊöÁËÁòËáÍ·æßà­ë¿×¢ÉäÒºÔÚÖí¡¢Å£ºôÎüϵͳ¸ÐȾ¼°ÄÌÅ£Èé·¿Ñ×ÖÎÁÆÖеÄÂõ²©ÌåÓýÓÃ,ÒÔÆÚΪÁÙ´²Ê¹ÓÃÌṩ²Î¿¼¡£ 
 
ÎÄÏ×À´Ô´£ºÖйúÊÞÒ©ÔÓÖ¾  2013Äê08ÆÚ
×÷Õßµ¥Î»£º ¹ú¼ÒÊÞÓÃÒ©Æ·¹¤³Ì¼¼ÊõÑо¿ÖÐÐÄ
 
5. ¡¶¸´·½²ÎÜ˶ԷÀÖ¹Ðļ¡Ï¸°ûÃâÊÜȮϸС²¡¶¾ËðÉ˵ı£»¤ºÍ¿¹Ñõ»¯×÷Óá·
¡¾ÕªÒª¡¿£º Ä¿µÄ:̽ÌÖ¸´·½²ÎÜË·ÀÖ¹Ðļ¡Ï¸°ûÃâÊÜȮϸС²¡¶¾ËðÉ˵ı£»¤ºÍ¿¹Ñõ»¯×÷ÓÃ.·½·¨:ÅàÑøµÄÈéÊóÐļ¡Ï¸°û,¼ÓÈëȮϸС²¡¶¾ÒºÖÂÐļ¡Ï¸°û²¡¶¾ÐÔÑõ»¯ËðÉË,²â¶¨ÈéÊóÐļ¡Ï¸°ûÁѽâÒºÖÐSOD,MDA¼°ÓÃMTT·¨²â¶¨Ï¸°û»îÐÔ,̽¾¿¸´·½²ÎÜË·ÀÖ¹Ðļ¡Ï¸°ûÃâÊÜȮϸС²¡¶¾ËðÉ˵ı£»¤ºÍ¿¹Ñõ»¯×÷ÓÃ.½á¹û:²¡¶¾ËðÉË×éϸ°û±£»¤ÂÊΪ70.67%±1.33%,¸´·½²ÎÜ˸ß¡¢ÖС¢µÍ¼ÁÁ¿×éϸ°û±£»¤ÂÊ·Ö±ðΪ83.52%,92.35%,80.72%,Ó벡¶¾ËðÉË×éÏà±ÈÓм«ÏÔÖøÐÔ²îÒì(p<0.01);²¡¶¾ËðÉË×éϸ°ûÁѽâÒºÖÐSOD»îÐÔ½µµÍ,MDAÖÊÁ¿·ÖÊýÔö¸ß,¶ø¸´·½²ÎÜË×éÉÏÊöÖ¸±êÓÐËù¸ÄÉÆ,ÆäÖÐSOD»îÐÔÉý¸ß,MDA½µµÍ,ÓëÄ£ÐÍ×éÏà±È²îÒ켫ÏÔÖø(p<0.01).½áÂÛ:¸´·½²ÎÜË¿É·ÀÖ¹Ðļ¡Ï¸°ûÃâÊÜȮϸС²¡¶¾ËðÉË,Æä»úÀí¿ÉÄÜÓëÔöǿϸ°û¿¹Ñõ»¯×÷ÓᢼõÉÙ×ÔÓÉ»ùºÍÖ¬ÖʹýÑõ»¯µ¼ÖµÄϸ°ûËðÉËÓÐÂõ²©ÌåÓý.
 
ÎÄÏ×À´Ô´£ºÎ÷ÄÏ´óѧѧ±¨(×ÔÈ»¿Æѧ°æ)  2013Äê07ÆÚ 
×÷Õßµ¥Î»£º Î÷ÄÏ´óѧ(ÈÙ²ýУÇø)¶¯Îïҽѧϵ£» ÖØÇìÊÐҩЧÆÀ¼Û¹¤³Ì¼¼ÊõÑо¿ÖÐÐÄ
 
6. ¡¶¼¦Íȹ½¾ÆÔã¾ú¿·¶ÔÌ츮ÈâѼ³¦µÀÐÎ̬¼°ÆäÖÐÖ÷Òª¾úȺµÄÓ°Ïì¡·
¡¾ÕªÒª¡¿£º ÎªÆÀ¼Û¼¦Íȹ½¾ÆÔã¾ú¿·¶ÔÈâѼ³¦µÀÐÎ̬¼°Ö÷Òª¾úȺµÄÓ°Ïì,Ñ¡ÓÃ320Ö»1ÈÕÁ佡¿µÌ츮ÈâѼΪÑо¿¶ÔÏó,Ëæ»ú·Ö³É¶ÔÕÕ×é¡¢ÊÔÑé¢ñ×é¡¢ÊÔÑé¢ò×éºÍÊÔÑé¢ó×é¹²4×é,4Áý/×é(ÆäÖÐ2ÁýΪÐÛÐÔ,2ÁýΪ´ÆÐÔ),20Ö»/Áý.ÿ×é4¸öÖظ´,ÿ¸öÖظ´20Ö»,¶ÔÕÕ×éËÇι»ù´¡ËÇÁ¸,ÊÔÑé¢ñ,¢ò,¢ó×éËÇι·Ö±ðÌí¼Ó2%¡¢4%ºÍ6%¼¦Íȹ½¾ÆÔã¾ú¿·µÄÊÔÑéËÇÁ¸.½á¹ûÏÔʾ:Óë¶ÔÕÕ×éÏà±È,3¸öÊÔÑé×é14ÈÕÁäÈâѼ»Ø³¦ÈÞë¸ß¶È¾ùÓÐËù½µµÍ,28ÈÕÁäÈâѼ»Ø³¦ÒþÎÑÉî¶È¾ùÓÐËùÔö¼Ó(p<0.05);ÊÔÑé¢ñ×éºÍÊÔÑé¢ò×é¾ùÓÐÔö¼ÓÈâѼ䳦˫Æç¸Ë¾úºÍÈéËá¸Ë¾úÊýÁ¿µÄÇ÷ÊÆ(p<0.05),¶Ô´ó³¦¸Ë¾úÎÞÏÔÖøÓ°Ïì(p>0.05).±íÃ÷¼¦Íȹ½¾ÆÔã¾ú¿·¶ÔÌ츮ÈâѼ»Ø³¦ð¤Ä¤ÐÎ̬ÓÐÒ»¶¨µÄËðÉË,¶ÔÈâѼ䳦ÓÐÒæ΢ÉúÎï¾úȺÓÐÒ»¶¨µÄ´Ù½ø×÷ÓÃ.
 
ÎÄÏ×À´Ô´£ºÎ÷ÄÏ´óѧѧ±¨(×ÔÈ»¿Æѧ°æ) 2013Äê08ÆÚ 
×÷Õßµ¥Î»£º Ò˱öѧԺÉúÃü¿ÆѧÓëʳƷ¹¤³ÌѧԺ£» Ò˱öѧԺ·¢½Í×ÊÔ´ÓëÂõ²©ÌåÓýÓÃËÄ´¨Ê¡¸ßУÖصãʵÑéÊÒ£» ËÄ´¨Å©Òµ´óѧ¶¯ÎïҽѧԺ
 
7. ¡¶Å©Ò©äåÇè¾Õõ¥·Ö×ÓÓ¡¼£¾ÛºÏÎïµÄÖƱ¸¼°ÐÔÄÜÑо¿¡·
¡¾ÕªÒª¡¿£º ÒÔÅ©Ò©äåÇè¾Õõ¥ÎªÄ£°å·Ö×Ó,±ûÏ©õ£°·(AM)Ϊ¹¦Äܵ¥Ìå,ÒÒ¶þ´¼¶þ¼×»ù±ûÏ©Ëáõ¥(EGDMA)Ϊ½»Áª¼Á,²ÉÓóÁµí¾ÛºÏ·¨ºÏ³ÉÁ˶ÔäåÇè¾Õõ¥¾ßÓи߶ÈÑ¡ÔñÐԵķÖ×ÓÓ¡¼£¾ÛºÏÎï(MIP).ͨ¹ýƽºâÎü¸½ÊµÑé,ÆÀ¼ÛÆä¶ÔäåÇè¾Õõ¥µÄÇ׺ÍÁ¦ºÍÑ¡ÔñÐÔ.½á¹û±íÃ÷,Óë¿Õ°×NIPÏà±È,äåÇè¾Õõ¥MIP¶ÔäåÇè¾Õõ¥±íÏÖ³ö½Ï¸ßµÄÇ׺ÍÁ¦.Scatchard·½³Ì·ÖÎö±íÃ÷,äåÇè¾Õõ¥MIPÉÏÓÐÁ½À಻ͬÐÔÖʵĽáºÏλµã,Á½ÖÖ½áºÏλµãµÄ½âÀë³£Êý·Ö±ðΪKD1=2.99mg/LºÍKD2=57.14mg/L,¶ÔäåÇè¾Õõ¥µÄ×î´ó±í¹Û½áºÏÁ¿·Ö±ðΪQmax=2.22mL/LºÍQmax=16.54mL/L.½«¸Ã¾ÛºÏÎïÂõ²©ÌåÓýÓÃÓÚ¹ÌÏàÝÍÈ¡ÖÐ,ÒÔÃÛéÙΪÑùÆ·µÄ¼Ó±ê»ØÊÕʵÑé±íÃ÷,äåÇè¾Õõ¥MIP¹ÌÏàÝÍÈ¡¾»»¯·½·¨µÄ׼ȷ¶ÈΪ90%¡«93%,ÒÑ´ïµ½¸´ÔÓ»ùÖÊÖжÔäåÇè¾Õõ¥µÄ¼ì²âÒªÇó,ÓëÐÐÒµ±ê×¼²â¶¨½á¹ûÎÞÏÔÖøÐÔ²îÒì.
 
ÎÄÏ×À´Ô´£ºÎ÷ÄÏ´óѧѧ±¨(×ÔÈ»¿Æѧ°æ) 2013Äê08ÆÚ 
×÷Õßµ¥Î»£º Î÷ÄÏ´óѧʳƷ¿ÆѧѧԺ£» ÖØÇìÊÐÌØɫʳƷ¹¤³Ì¼¼ÊõÑо¿ÖÐÐÄ£» Å©Òµ²¿Å©Âõ²©ÌåÓýÆ·Öü²Ø±£ÏÊÖÊÁ¿°²È«·çÏÕÆÀ¹ÀʵÑéÊÒ£»
 
8. ¡¶½¡Æ¢ÒæÆøÌÀ¶ÔÃâÒßÒÖÖÆÐÍСÊóÃâÒß¹¦ÄܵÄÓ°Ïì¡·
¡¾ÕªÒª¡¿£º ¡¾Ä¿µÄ¡¿Ì½ÌÖ½¡Æ¢ÒæÆøÌÀ¶ÔÃâÒßÒÖÖÆСÊóÃâÒß¹¦ÄܵÄÓ°Ïì¡£¡¾·½·¨¡¿¸øСÊóƤÏÂ×¢Éä»·Á×õ£°·(CTX)30mg/(kg·d),ÖƱ¸ÃâÒßÒÖÖÆÄ£ÐÍ;ÒõÐÔ¶ÔÕÕ×éСÊó¹àθÉúÀíÑÎË®,ÑôÐÔ¶ÔÕÕ×é¹àθ0.1g/(kg·d)×óÐýßäßò,½¡Æ¢ÒæÆøÌÀµÍ¼ÁÁ¿¸øÒ©×é(16g/(kg·d))ºÍ¸ß¼ÁÁ¿¸øÒ©×é(44g/(kg·d))·Ö±ð¹àθ½¡Æ¢ÒæÆøÌÀ,Ñо¿½¡Æ¢ÒæÆøÌÀ¶ÔСÊóÌåÖÊÁ¿¡¢Æ¢ÔàÖ¸ÊýÒÔ¼°ÑªÇåÖÐIgG¡¢IL-2¡¢TNF-αÖÊÁ¿Å¨¶ÈºÍTÁÜ°Íϸ°ûÑÇȺÖÐCD4+¡¢CD8+ÊýÁ¿µÄÓ°Ïì¡£¡¾½á¹û¡¿½¡Æ¢ÒæÆøÌÀµÍ¼ÁÁ¿¸øÒ©×éºÍ¸ß¼ÁÁ¿¸øÒ©×é¾ùÄÜÞ׿¹ÓÉ»·Á×õ£°·Ëùµ¼ÖµÄÌåÖÊÁ¿Ï½µ,½¡Æ¢ÒæÆøÌÀ¸ß¼ÁÁ¿×éÏÔÖø½µµÍÁËÃâÒßÒÖÖÆСÊóµÄÆ¢ÔàÖ¸Êý¡£½¡Æ¢ÒæÆøÌÀ¿ÉÒÔÃ÷ÏÔÌá¸ßÃâÒßÒÖÖÆСÊóѪÇåÖеÄIgG¡¢IL-2ºÍTNF-αÖÊÁ¿Å¨¶È,Ôö¼ÓÃâÒßÒÖÖÆСÊóÍâÖÜѪÖÐTÁÜ°Íϸ°ûCD4+ÊýÁ¿,½µµÍCD8+ÊýÁ¿,ʹCD4+/CD8+Ìá¸ß¡£¡¾½áÂÛ¡¿½¡Æ¢ÒæÆøÌÀÄÜÔöÇ¿ÃâÒßÒÖÖÆСÊóµÄÃâÒß¹¦ÄÜ¡£ 
 
ÎÄÏ×À´Ô´£ºÎ÷±±Å©ÁֿƼ¼´óѧѧ±¨(×ÔÈ»¿Æѧ°æ) 2013Äê08ÆÚ 
×÷Õßµ¥Î»£º ºÓ±±±±·½Ñ§Ôº¶¯Îï¿Æ¼¼Ñ§Ôº£» ºÓ±±ÀÈ·»Êдó³§ÐóÄÁÊÞÒ½¾Ö£» ºÓ±±ÂÃÓÎְҵѧԺ
 
9£®¡¶Í·æß¿Ëë¿ÄÉÃ×ÈéµÄÖƱ¸¼°ÆäÌåÍâÒÖ¾ú»îÐԲⶨºÍ°²È«ÐÔÆÀ¼Û¡·
¡¾ÕªÒª¡¿£º¡¾Ä¿µÄ¡¿ÖƱ¸Í·æß¿Ëë¿ÄÉÃ×Èé,¿¼²ìÆäÀí»¯ÐÔÖÊ,²¢½øÐÐÌåÍâÒÖ¾ú»îÐÔ¼ì²âºÍ°²È«ÐÔÆÀ¼Û¡£¡¾·½·¨¡¿ÀûÓÃαÈýÔªÏàͼ·¨É¸Ñ¡Í·æß¿Ëë¿ÄÉÃ×ÈéÅä·½,ÖƱ¸Í·æß¿Ëë¿ÄÉÃ×Èé,ÓÃ͸Éäµç¾µ¡¢¼¤¹âÁ£¶È·ÖÎöÒǶÔÆä½øÐÐÐÎ̬ºÍÁ£¾¶·ÖÎö;²ÉÓÃ΢Á¿ÈâÌÀÏ¡ÊÍ·¨,¼ì²âÍ·æß¿Ëë¿ÄÉÃ×Èé¶ÔÖ²¡ÐԴ󳦰£Ï£¾ú¡¢½ð»ÆÉ«ÆÏÌÑÇò¾ú¡¢É³ÃÅÊϾú¡¢ÎÞÈéÁ´Çò¾úºÍ²»¶¯¸Ë¾úµÄ×îСÒÖ¾úŨ¶È(MIC)ºÍ×îСɱ¾úÖÊÁ¿Å¨¶È(MBC),ͨ¹ý¼±ÐÔ¶¾ÐÔÊÔÑ鿼²ìÆ䰲ȫÐÔ¡£¡¾½á¹û¡¿Í·æß¿Ëë¿ÄÉÃ×ÈéÖи÷×é·ÖµÄÖÊÁ¿·ÖÊýΪ:EL-40 27.1%¡¢Èâ¹ðÈ©6.8%¡¢Í·æß¿Ëë¿2.0%¡¢ÕôÁóË®64.1%¡£ÖƱ¸µÄÍ·æß¿Ëë¿ÄÉÃ×ÈéΪdz»ÆÉ«³ÎÇå͸Ã÷ÒºÌå,͸Éäµç¾µÏÂΪ¹æÔòÔ²ÇòÐÎ,Á£¾¶·Ö²¼ÔÚ6¡«20nm,ƽ¾ùÁ£¾¶Îª12.1nm,¶à·ÖɢϵÊý(PDI)Ϊ0.141,·ÖÉ¢ÐÔÁ¼ºÃ¡£ÌåÍâÒÖ¾úÊÔÑé±íÃ÷,Í·æß¿Ëë¿ÄÉÃ×Èé¶ÔÖ²¡ÐԴ󳦰£Ï£¾ú¡¢½ð»ÆÉ«ÆÏÌÑÇò¾ú¡¢É³ÃÅÊϾú¡¢ÎÞÈéÁ´Çò¾úºÍ²»¶¯¸Ë¾úµÄMIC·Ö±ðΪ1,4,4,2,8μg/mL,MBC·Ö±ðΪ2,8,8,4,16μg/mL,ÒÖ¾úЧ¹ûÃ÷ÏÔÓÅÓÚÆäËû¶ÔÕÕÒ©Îï¡£¼±ÐÔ¶¾ÐÔÊÔÑé±íÃ÷,Í·æß¿Ëë¿ÄÉÃ×ÈéµÄLD50Ϊ4 116mg/kg,ÊôÓڵͶ¾Ò©Îï,°²È«ÐÔÁ¼ºÃ¡£¡¾½áÂÛ¡¿³É¹¦ÑÐÖÆÁËÍ·æß¿Ëë¿ÄÉÃ×Èé,ÌåÍâÒÖ¾úЧ¹ûÃ÷ÏÔ,ÊôÓڵͶ¾Ò©Îï,¾ßÓÐÁ¼ºÃµÄ°²È«ÐÔ¡£ 
 
ÎÄÏ×À´Ô´£ºÎ÷±±Å©ÁֿƼ¼´óѧѧ±¨(×ÔÈ»¿Æѧ°æ) 2013Äê07ÆÚ 
×÷Õßµ¥Î»£º Î÷±±Å©ÁֿƼ¼´óѧ¶¯ÎïҽѧԺ
 
10£®¡¶ÒÁά¾úËØÌåÍâ͸ƤÎüÊÕÓ°ÏìÒòËصÄÑо¿¡·
¡¾ÕªÒª¡¿£º²ÉÓøÄÁ¼FranzÀ©É¢³Ø,ÒÔÀëÌå´óÊóƤ·ôΪ͸ƤÆÁÕÏ,¿¼²ì´Ù½ø¼ÁµªÍª¡¢èñÒ¶ÓÍ¡¢±ùƬµÈÒÔ¼°ÖúÈÜ´ÙÉø¼Á¶þ¼×»ùÑÇí¿¡¢±û¶þ´¼¡¢Òì±û´¼¶ÔÒÁά¾úËØÌåÍâ͸ƤÎüÊÕ´Ù½øЧ¹û,²¢Õý½»É¸Ñ¡´Ù½ø¼Á¼°ÖúÈܼÁµÄ×î¼Ñ×éºÏ,̽ÌÖÒÁά¾úËØÌåÍ⾭ƤÉø͸µÄÓ°Ïì¡£½á¹û±íÃ÷:µ¥¶ÀʹÓöþ¼×»ùÑÇí¿¡¢±ùƬ¡¢èñÒ¶ÓÍ´ÙÉøЧ¹û½ÏºÃ,ÔöÉø±¶Êý·ÖΪ4.99¡¢4.60¡¢4.00;¸´ºÏ´Ù½ø¼ÁÒÔèñÒ¶ÓÍ4%+µªÍª1.5%+±ùƬ3.5%×éºÏ´Ù͸ÐÔ×îºÃ,ÔöÉø±¶Êý´ïµ½24.62±¶;ÔÚ×î¼Ñ¸´ºÏ´Ù½ø¼Á»ù´¡ÉÏ,±û¶þ´¼15%+¶þ¼×»ùÑÇí¿35%+Òì±û´¼15%×éºÏÖúÈÜ´ÙÉøЧ¹û×î¼Ñ,ÔöÉø±¶Êý´ï29.48±¶;Öظ´5´Î,ÔöÉø±¶Êý´ï(28.01±4.02)%¡£Ö¤Ã÷ÒÔèñÒ¶ÓÍ4%+µªÍª1.5%+±ùƬ3.5%+±û¶þ´¼15%+¶þ¼×»ùÑÇí¿35%+Òì±û´¼15%×éºÏÖƱ¸µÄ1%ÒÁά¾úËØ͸Ƥ¼Á,ÌåÍâ͸ƤÐÔÄÜ×îºÃ¡£ 
 
ÎÄÏ×À´Ô´£ºÑïÖÝ´óѧѧ±¨(Å©ÒµÓëÉúÃü¿Æѧ°æ) 2013Äê02ÆÚ 
×÷Õßµ¥Î»£º ÄϾ©Å©Òµ´óѧ¶¯ÎïҽѧԺ£» ½­ËÕÐóÄÁÊÞÒ½Ö°Òµ¼¼ÊõѧԺ
 
11. ¡¶Î÷°²µØÇøÑòÄ̵ijɷֺÍù¾ú¶¾ËØÎÛȾ״¿öÑо¿¡·
¡¾ÕªÒª¡¿£º ÎªÑо¿Î÷°²µØÇøÑòÄ̵ijɷֺÍù¾ú¶¾ËØÎÛȾ״¿ö,²É¼¯ÁËÎ÷°²ÊÐ70Åú´ÎÉúÏÊÑòÄÌÑùÆ·ºÍ30Åú´ÎÑòÄÌ·ÛÑùÆ·,ÀûÓÃMilkscanÈé³É·Ö²â¶¨ÒǺÍÒºÏàÉ«Æ×´®ÁªÖÊÆ×·¨¼ì²âÑòÄ̵ÄÖÊÁ¿Ö¸±ê(µ°°×¡¢Ö¬·¾ºÍÌåϸ°ûÊý)ºÍù¾ú¶¾ËØÎÛȾ״¿ö(»ÆÇúù¶¾ËØM1¡¢ô÷Çúù¶¾ËØA¡¢α-ÓñÃ׳àùϩ´¼ºÍÓñÃ׳àùϩͪ)¡£½á¹û±íÃ÷:1)ÉúÏÊÑòÄ̵ÄÈéµ°°×¡¢ÈéÖ¬·¾ºÍÌåϸ°ûÊýƽ¾ùΪ3.6%¡¢4.1%ºÍ116.9Íòcells/mL;2)»ÆÇúù¶¾ËØM1¡¢ô÷Çúù¶¾ËØA¡¢α-ÓñÃ׳àùϩ´¼ºÍÓñÃ׳àùϩͪÔÚÉúÏÊÑòÄÌÖмì³öÂʺÍƽ¾ùº¬Á¿·Ö±ðΪ98.1%ºÍ12.4ng/kg¡¢80%ºÍ96.6ng/kg¡¢77.1%ºÍ74.5ng/kg¡¢80.0%ºÍ36.2ng/kg,ÔÚÑòÄÌ·ÛÖмì³öÂʺÍƽ¾ùº¬Á¿·Ö±ðΪ100%ºÍ57.3ng/kg¡¢37.0%ºÍ37.1ng/kg¡¢60.0%ºÍ59.8ng/kg¡¢100%ºÍ97.1ng/kg,ËùÓÐÑùÆ·ÖÐù¾ú¶¾Ëغ¬Á¿¶¼´¦ÓÚºÛÁ¿Ë®Æ½,Ô¶µÍÓÚ»ÆÇúù¶¾ËØM1µÄ¹ú¼ÒÏÞÁ¿(500ng/kg);3)»ÆÇúù¶¾ËØM1ÏÔÖøÓ°ÏìÈéµ°°×º¬Á¿(P<0.01),α-ÓñÃ׳àùϩ´¼Ò²ÏÔÖøÓ°ÏìÌåϸ°ûÊý(P<0.001),ÓñÃ׳àùϩͪºÍα-ÓñÃ׳àùϩ´¼¡¢Èéµ°°×ÓëÈéÖ¬·¾¼ä´æÔÚÏÔÖøÏàÂõ²©ÌåÓýÐÔ(P<0.01)¡£½á¹ûÏÔʾ,Ä¿Ç°Î÷°²µØÇøÑòÄÌÖÊÁ¿ÔÚ°²È«·¶Î§,µ«Ã¹¾ú¶¾ËØÎÛȾµÄ·çÏÕ»¹Âõ²©ÌåÓýÒýÆðÈËÃǵľ¯Ìè¡£
 
ÎÄÏ×À´Ô´£ºÖйúÅ©Òµ´óѧѧ±¨2013Äê05ÆÚ 
×÷Õßµ¥Î»£º °²»ÕÅ©Òµ´óѧ¶¯Îï¿Æ¼¼Ñ§Ôº£» ÖйúÅ©Òµ¿ÆѧԺ±±¾©ÐóÄÁÊÞÒ½Ñо¿Ëù/¶¯ÎïÓªÑø¹ú¼ÒÖصãʵÑéÊÒ£» Å©Òµ²¿Ä̼°ÄÌÖÆÆ·ÖÊÁ¿¼à¶½¼ìÑé²âÊÔÖÐÐÄ(±±             ¾©)£» Å©Òµ²¿ÄÌÂõ²©ÌåÓýÆ·ÖÊÁ¿°²È«·çÏÕÆÀ¹ÀʵÑéÊÒ(±±¾©)
 
12. ¡¶ºì»¨»ÆÉ«ËضԶÏÄÌ×ÐÖíÉúÂõ²©ÌåÓýÐÔÄܺͿ¹Ñõ»¯ÄÜÁ¦µÄÓ°Ïì¡·
¡¾ÕªÒª¡¿£ºÊÔÑéÖ¼ÔÚ̽Ìֺ컨»ÆÉ«ËضԶÏÄÌ×ÐÖíÉúÂõ²©ÌåÓýÐÔÄܺͿ¹Ñõ»¯ÄÜÁ¦µÄÓ°Ïì¡£ÊÔÑé²ÉÓõ¥Òò×ÓËæ»ú·Ö×éÉè¼Æ,Ñ¡È¡30ÈÕÁäÈýÔªÔÓ½»(¶Å׳¤×´ó)×ÐÖí72Í·,Ëæ»ú·Ö³É4×é(¶ÔÕÕ×éºÍÊÔÑé1¡¢2¡¢3×é),ÿ×é3¸öÖظ´,·Ö±ðËÇιº¬0%¡¢0.01%¡¢0.03%¡¢0.06%ºì»¨»ÆÉ«ËصÄÈÕÁ¸,ÊÔÑéΪÆÚ30d¡£½á¹û±íÃ÷ÔÚËÇÁÏÀïÌí¼Óºì»¨»ÆÉ«ËØÄÜÌá¸ß¶ÏÄÌ×ÐÖíµÄÉú³¤ÐÔÄܺͿ¹Ñõ»¯ÄÜÁ¦,ÇÒÌí¼Ó0.03%ºì»¨»ÆÉ«ËØЧ¹û×îºÃ¡£ 
 
ÎÄÏ×À´Ô´£ºÖÐÊÞҽѧÔÓÖ¾2013Äê04ÆÚ 

×÷Õßµ¥Î»£º ºÓÄÏÊ¡ÓݳÇÏØÐóÄÁ¾Ö



  • ¹úÍâÔÓÖ¾ÕªÒª


1. <Cello-oligosaccharide ameliorates heat stress-induced impairment of intestinal microflora, morphology and barrier integrity in broilers>
¡¾ÕªÒª¡¿£º±¾ÎÄÑо¿ÁË´óÌáÇٵ;ÛÌǶÔÈ⼦ÓÉÓÚÈÈÂõ²©ÌåÓý¼¤¶øµ¼Öµij¦µÀÄÚ»·¾³±ä»¯µÄ¸ÄÉÆÄÜÁ¦¡£×÷ÕßÑ¡È¡360Ö»21ÈÕÁäµÄÂÞ˹308ÐÛÐÔÈ⼦£¬¸ù¾ÝÊÇ·ñ½ÓÊÜÈÈÂõ²©ÌåÓý¼¤´¦ÀíºÍÊÇ·ñιËÇ1.5g/kg´óÌáÇٵ;ÛÌÇÁ½Á½ÎöÒò·Ö×飬·ÖΪ4¸ö´ó×飬ÿ¸ö´ó×é°üº¬6¸öÖظ´Ð¡×飬ÿ×é15Ö»È⼦¡£ÈÈÂõ²©ÌåÓý×éÿÌì8µãµ½18µã£¬ÊÒÎÂÉ趨Ϊ33¡æ£¬18µãµ½µÚ¶þÌì8µã£¬ÊÒÎÂÉ趨Ϊ22¡æ£¬Ö±µ½µÚ42ÈÕʵÑé½áÊø¡£ÊµÑé½á¹û±íÃ÷£¬ÈÈÂõ²©ÌåÓý¼¤»áµ¼ÖÂÈ⼦ƽ¾ùÈÕÔöÖغÍƽ¾ùÈÕ²ÉʳÁ¿ÏÔÖøϽµ£¬¿Õ³¦ÈÞ볤¶ÈÒÔ¼°ÈÞë¸ß¶ÈÓëÒþÎÑÉî¶È±ÈÒàϽµ£¬Ã¤³¦ÄÚÈéËá¾ú»î¾úÊýºÍ¿Õ³¦¿çĤµç×è½µµÍ£»Í¬Ê±Ã¤³¦´ó³¦¸Ë¾ú»î¾úÊýºÍ¿Õ³¦¶ÔÒìÁòÇèËáÓ«¹âËØÆϾÛÌǵÄͨ͸ÐÔÔòÉý¸ß¡£¶øιËÇ´óÌáÇٵ;ÛÌÇ£¬ÄܺܺõĸÄÉÆÒÔÉÏÐðÊöµÄ±ä»¯£¬°µÊ¾´óÌáÇٵ;ÛÌÇÄÜÂõ²©ÌåÓýÓÃÓÚ¿¹ÈÈÂõ²©ÌåÓý¼¤ÖÎÁÆ¡£
ÎÄÏ×À´Ô´£ºAnimal Feed Science and Technology
Volume 185, Issues 3–4, 25 October 2013, Pages 175–181
 
2. <Ingestion of medium chain fatty acids by lactating dairy cows increases concentrations of plasma ghrelin>
¡¾ÕªÒª¡¿£º±¾ÎÄÑо¿ÁËËÇÁÏÖмÓÈëÖÐÁ´Ö¬·¾Ëá¶ÔÔçÆÚÃÚÈéÆÚÄÌţѪ½¬ÖÐÉú³¤Ëغ¬Á¿µÄÓ°Ïì¡£×÷ÕßÑ¡È¡5Í·ºÉ˹̹ÄÌÅ££¬Ëæ»ú·ÖΪÁ½×飬һ×é°´¸ÉËÇÁÏÖØ1.5%¼ÓÈëÖÐÁ´Ö¬·¾Ëá¸ÆÑΣ¨MCFA-Ca£©£¬ÁíÒ»×éΪ¶ÔÕÕ×顣ÿ14ÌìÓÚÉÏÎç²É¼¯¸÷Ñù±¾µÄ¾±¾²ÂöѪ£¬²âÁ¿Ñª½¬¼¤ËغʹúлÎïŨ¶È¡£ÊµÑé½á¹û±íÃ÷£¬ËÇÁÏÖÐÌí¼ÓMCFA-Ca£¬»áµ¼ÖÂÄÌÅ£µÄ²ÉʳÁ¿¡¢Âõ²©ÌåÓýÄÌÁ¿ºÍÄÌÖÐÈéÌǺ¬Á¿µÄ½µµÍ£¬µ«¶ÔÄ̵ÄÕûÌåÖÊÁ¿ÎÞÓ°Ï졣Ѫ½¬ÖеÄÉú³¤ËØŨ¶È»áÌá¸ß£¬ÒȵºËغ¬Á¿ÉÏÉý£¬µ«ÒȸßѪÌÇËØÔò²»ÊÜÓ°Ïì¡£´ËÍâ·Çõ¥»¯Ö¬·¾Ëá¡¢×ܵ¨¹Ì´¼ºÍβ-ôÇ»ù¶¡µÄº¬Á¿Ò²ÉÏÉý¡£
ÎÄÏ×À´Ô´£ºDomestic Animal Endocrinology
Volume 45, Issue 4, November 2013, Pages 216–223
 
3. <Design of antibiotic containing hydrogel wound dressings: Biomedical properties and histological study of wound healing>
¡¾ÕªÒª¡¿£º½éÉÜÁËÒ»ÖÖÓÃÓÚ´´¿ÚÓúºÏµÄ¿¹¾úË®Äý½º·óÁϵÄÉúÎïѧÓë×é֯ѧÑо¿¡£×÷Õß·ÖÎöÁË´Ì»±½ºµÄ¿¹Ñõ»¯ÐԺͿ¨²¨Ä·Ë®Äý½ºµÄð¤Ä¤ð¤¸½ÄÜÁ¦£¬ÊÔͼ¼õ»º·óÁÏÄÚÇì´óùËصÄÊÍ·ÅËٶȣ¬Ôö¼ÓÆä´´¿ÚÖÎÁÆÄÜÁ¦¡£Ë®Äý½ºÄ¤µÄÐÔ×´ÓÉɨÃèµç×ÓÏÔ΢¾µ¡¢¸µÊÏת»»ºìÍâÏß¹âÆ×·ÖÎöÒǺÍX¹âÉ¢Éä¼¼Êõ½øÐзÖÎö£¬ÉúÎïѧÐÔÄÜÖ÷ÒªÑо¿ÑªÒºÏàÈÝÐÔ¡¢¿¹Ñõ»¯»îÐÔ¡¢ð¤Ä¤ð¤¸½ÄÜÁ¦¡¢¿¹¾ú»îÐÔ¡¢ÑõÆø/Ë®ÕôÆøÉø͸ÐÔ¡¢Î¢ÉúÎïÉø͸ÐÔºÍÁ¦Ñ§ÐÔÖÊ£¨¿¹À­Ç¿¶È¡¢±¬ÁÑÇ¿¶È¡¢µ¯ÐÔ¡¢ËɳÚÐÔ¡¢ÄÍÕ۶ȣ©£¬Í¬Ê±ÔÚÈðÊÏ°×»¯ÊóÉíÉÏÑо¿×é֯ѧʵÑé¡£½á¹û±íÃ÷¸ÃË®Äý½ºÄܼÓËÙÉË¿ÚÓúºÏ£¬Ôö¼Ó³ÉÏËάϸ°ûºÍëϸѪ¹ÜµÄÉú³É£¬²»ÈÜѪ£¬²»µ¼ÖÂѪ˨µÄÐγÉ£¬Ë®¡¢Ñõ͸ÆøÐԺõ«¶Ô΢ÉúÎïÓкܺõÄ×è¸ô×÷Óá£
ÎÄÏ×À´Ô´£ºInternational Journal of Pharmaceutics
Volume 457, Issue 1, 30 November 2013, Pages 82–91

Âõ²©ÌåÓý:  

4. <Enhanced bioavailability of poorly absorbed hydrophilic compounds through drug complex/in situ gelling formulation>
¡¾ÕªÒª¡¿£ºBCSÈý¼¶Ç×Ë®»¯ºÏÎïÓÉÓÚÆä½ÏµÍµÄθ³¦Í¨Í¸ÐÔ£¬ÆäÉúÎïÀûÓöÈÒ»Ö±±È½ÏµÍ¡£±¾ÎÄÀûÓÃÒ»ÖÖеķÖ×ÓʵÌ壨RWJ-445167£©×÷ΪÑо¿¶ÔÏó£¬ÏÈÓëÔ¹ð»ùÁòËáÄÆ»¯ºÏ£¬ÔÙÓëԭλ½ºÄýճĤ½ºð¤¼ÁÔØÌå¾ÛÑõÒÒÏ©±ÍÂéÓÍ×éºÏ£¬½øÐбíÕ÷ºÍ´óÊóÌåÄÚÒ©´ú¶¯Á¦Ñ§Ñо¿¡£½á¹û±íÃ÷£¬RWJÓëÔ¹ð»ùÁòËáÄÆ»¯ºÏºó£¬ÆäË®ÈÜÐÔ´Ó61mg/ml½µÖÁ0.58mg/ml£¬µ«·ÖÅäϵÊýÔò´Ó0.05ÉýÖÁ7.59 £¬ÔÚ´óÊóÌåÄÚ½øÐÐÊ®¶þÖ¸³¦¸øÒ©²¢Ñо¿Ò©´ú¶¯Á¦Ñ§£¬·¢ÏÖÆäÉúÎïÀûÓöȴÓ4.26%ÉýÖÁ28.24%£¬±íÃ÷¸ÃÖÖ´¦Àí·½·¨ÄÜÓÐЧÔö¼Ó¸Ã»¯ºÏÎïµÄÉúÎïÀûÓöÈ¡£
ÎÄÏ×À´Ô´£ºInternational Journal of Pharmaceutics
Volume 457, Issue 1, 30 November 2013, Pages 63–70
 
5. <Development of intravenous lipid emulsion of vinorelbine based on drug–phospholipid complex technique>
¡¾ÕªÒª¡¿£º±¾ÎÄÑо¿ÁËÒ©Î︨Á϶Գ¤´ºÈð±õ£¨Ò»ÖÖ¿¹Ö×ÁöÒ©£©µÄÐÔÄܵÄÓ°Ï졣ΪÁ˽µµÍÆä¾²Âö¶¾ÐÔ£¬×÷ÕßÀûÓÃÒ©ÎïÁ×Ö¬¸´ºÏ¼¼Êõ¸Ä½øÁ˳¤´ºÈð±õ¾²Âö×¢ÉäÒºÖ¬·¾È飬ͨ¹ýÁ×Ö¬ºÏ³ÉºóµÄ³¤´ºÈð±õÇ×Ö¬ÐÔÄܵõ½Ìá¸ß£¬Í¬Ê±Ò©ÐÔÎȶ¨¶øÎÞÉø©Çé¿ö·¢Éú¡£ÀûÓÃÍÃ×÷ΪʵÑ鶯Î¹Û²ìµ½×¢Éä¸ÃÖƼÁ¶ÔÍõĴ̼¤ÐԵͣ¬ÇÒÀûÓÃA547ÈËÀà·Î°©Ï¸°ûºÍBCAP37ÈËÀàÈéÏÙÁöϸ°û½ÓÖÖµÄСÊó×÷ΪʵÑé¶ÔÏ󣬹۲쵽¸ÃÖƼÁ¶ÔÖ×ÁöµÄÒÖÖÆÄÜÁ¦²¢Ã»ÓмõÉÙ¡£
ÎÄÏ×À´Ô´£ºInternational Journal of Pharmaceutics
Volume 454, Issue 1, 15 September 2013, Pages 472–477
 
6. <Reprint of: Nanocarrier systems for oral drug delivery: Do we really need them?>
¡¾ÕªÒª¡¿£º±¾ÎÄÑо¿ÁËÄÉÃ×ÔØÌå¶Ô¿Ú·þÀàÒ©ÎïÐÔÄܵÄÓ°Ïì²¢ÐðÊöÁËÏàÂõ²©ÌåÓýµÄÑо¿ºÍδÀ´µÄÕ¹Íû¡£ÄÉÃ×ÔØÌåµÄʹÓÃÊÇΪÁ˽â¾ö£º¢ÙÒ©ÎïÈܽâÐÔ²î¢ÚÒ©ÎïÉø͸ÐÔ²î¢ÛÒ©ÎïµÄ賦Îȶ¨ÐԵͣ¬¹ÌÌåÖ¬ÖÊÄÉÃ×Á£ºÍ¶à¿×Îü¸½¼Á¿ÅÁ£µÄʹÓðïÖúÕâÀàÒ©Îï·¢»Ó¸üºÃµÄÐÔÄÜ¡£Ö¤Ã÷Ô­ÔòÑо¿È·¶¨ÁËÄÉÃ×ÔØÌåÄÜÔö¼ÓÒ©ÎïµÄÎüÊÕºÍÀûÓ㬵«´Ó¾­¼Ã½Ç¶È³ö·¢µÄÑо¿»¹²»Ëã¶à¡£ÄÉÃ×ÔØÌåÄÜ°ïÖúÔö¼Ó¿Ú·þÒ©Îï¶Ôθ³¦Ã¸µÄµÖ¿¹ÄÜÁ¦£¬´Ó¶øÔö¼ÓÆäGIÎȶ¨ÐÔ£¬Í¬Ê±Ò²ÔÚÒ»¶¨³Ì¶ÈÉÏ´Ù½øÕ³ÒºÄý½º²ãÊÍ·ÅÏàÂõ²©ÌåÓýµÄÓÐЧÔغÉ£¬Ê¹µÃ´úлǰҩÎïÎÞ·¨±»ÎüÊÕ¡£½«À´µÄÄÉÃ×ÔØÌåÑо¿Ç÷Êƽ«¼¯ÖÐÔÚ²»½öÄÜÔö¼ÓÓëÖ®»¯ºÏµÄÒ©ÎïµÄÎüÊÕ£¬¸üÄÜÔö¼ÓÆäÊÍ·Å£¬Í¬Ê±¼õÉÙ¶Ôð¤ÒºÄý½º²ãÉø͸µÄÆÆ»µ¡£
ÎÄÏ×À´Ô´£ºEuropean Journal of Pharmaceutical Sciences
Volume 50, Issue 1, 27 September 2013, Pages 2–7
 
7. <Antioxidant capacity of spray-dried plant extracts: Experiments and simulations>
¡¾ÕªÒª¡¿£º±¾ÎÄÑо¿ÁËÅçÎí¸ÉÔï·¨¶ÔÖ²ÎïÌáÈ¡ÎÑõ»¯ÄÜÁ¦µÄÓ°Ïì¡£×÷ÕßÑ¡È¡Á˲»Í¬µÄ£¨70¡æµ½150¡æ£©½øÆøζÈ£¬ÀûÓÃBuchi B-290ÅçÎí¸ÉÔïÆ÷¶Ô¼¸ÖÖÉúÎï»îÐÔÈÜÒº½øÐÐÅçÎí¸ÉÔͬʱÉèÁ¢ÍÆÁ÷ʽÅçÎí¸ÉÔï×é×÷Ϊ¶ÔÕÕ×飬ÀûÓÃÑõ»¯»¹Ô­·¨²â¶¨Âõ²©ÌåÓýÎïµÄ¿¹Ñõ»¯ÄÜÁ¦¡£½á¹û±íÃ÷³öÆøζÈΪ60~65¡æ£¬½øÆøζÈΪ110¡æʱ£¬Âõ²©ÌåÓý³öÎïÄÜ´ïµ½65~70%£¬Óë²ÄÁÏÅú´ÎºÍÒºÌå½øÁÏËÙ¶ÈÎÞÂõ²©ÌåÓý¡£³öÆøζȶÔÌáÈ¡ÎïµÄ¿¹Ñõ»¯ÄÜÁ¦ÎÞÓ°Ï죬µ«½øÆøζȵÄÌá¸ßºÍÓɴ˵¼ÖµÄË®»îÐԵĽµµÍÔò¶Ô¿¹Ñõ»¯ÄÜÁ¦ÓÐÓ°Ïì¡£
ÎÄÏ×À´Ô´£ºAdvanced Powder Technology
Volume 24, Issue 4, July 2013, Pages 771–779

 

Âõ²©ÌåÓý(Öйú)¹Ù·½ÍøÕ¾